Tiny Solitary Soldier's blog, and the Gears of War Boardgame by Fantasy Flight Games. Both games, while certainly playable with more than one player, were designed around the idea that one player could tackle the game with the 'bad guys' as it were, controlled by the game mechanics.
This is something I have always been interested in, as much of the time I have 'available' for gaming is after my kids have gone to bed, or early in the morning on weekends, or late at night (or early in the morning again, depending on how you look at it) on school nights. So, not really available so much as there. In the past, I have always tried to just honestly play the other side of the board. In some games, such as Space Hulk, the enemy really lend themselves to it. How much though really goes into the Genestealers. What I usually did to compensate for this was just give an extra genestealer or two on each 'blip.'
Having a game available designed to do this from the very start really seems to cut out the middleman, so that I could enjoy a game whenever I darn well feel like it. What other games can you guys think of, and what are your opinions of how well they work?